Keywords: Quantitative Imaging, Contrast Mechanisms, MR Microscopy, Quantitative Susceptibility Mapping, R2*, Iron, Ferritin, Amyloid plaques, Alzheimer's Disease
Amyloid plaques, an established hallmark of Alzheimer's disease, are often demonstrably associated with iron deposits post-mortem. Previous T2*-weighted and phase information from ultra-high-field MR microscopy and clinical MRI has shown the potential to detect amyloid deposits in vivo and ex vivo. We investigated the relative contributions to contrast from amyloid-β (Aβ) aggregates with and without ferritin-bound iron in vitro, for R2* and quantitative susceptibility maps (QSM) with 86 μm isotropic resolution at 9.4T. We also demonstrated the quantitative signal evolution with the formation of amyloid aggregates, and the correlation of the signals with the Aβ and ferritin content.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords