Abstract #1258

Sex-specific changes and association in multiparametric MRI measurement at 3T in adult livers

Chia-Ying Liu¹, Chikara Noda², Rob van der Geest³, Bruno Triaire⁴, Yoshimori Kassai⁴, David A Bluemke⁵, and Joao Lima²

¹Canon Medical Systems Corporation, Ellicott City, MD, United States, ²Division of Cardiology, School of medicine, Johns Hopkins University, Baltimore, MD, United States, ³Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Canon Medical Systems Corporation, Tochigi, Japan, ⁵Department of Radiology, University of Wisconsin, Madison, WI, United States

Synopsis

Keywords: Quantitative Imaging, Liver, parametric mapping; PDFFImaging biomarkers derived from multiparametric MRI have been investigated for the evaluation of diffuse liver disease. We aimed to determine the sex-specific correlation of MRI parameters with age and BMI, and to evaluate the association between multiparametric MRI parameters. 100 study participants without known hepatic disease were prospectively enrolled. 3 T MRI including T1, T2 and T1ρ mapping and proton density fat fraction (PDFF) and R2* maps were acquired. Multiparametric MRI measures have sex-specific age and BMI dependency. Relaxometry mapping indices could be associated with PDFF. PDFF was significant associated with R2* and T1ρ, but not to T1 or T2.

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