Abstract #1261

Quantitative multiparametric MRI describes neuromelanin-linked pathogenesis in the AAV-hTyr rat model of Parkinson’s disease

Jean-Baptiste Pérot¹, Mathieu D Santin^1,2, Anthony Ruze^1,2, Lucas Soustelle³, Sana Rebbah¹, Laura Mouton¹, Romain Valabregue^1,2, Miquel Vila⁴, and Stéphane Lehéricy^1,2

¹Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, APHP, Hôpital de la Pitié Salpêtrière, Paris, France, ²Center for NeuroImaging Research (CENIR), Paris, France, ³Aix Marseille Univ, CNRS, CRMBM, Marseille, France, ⁴Neurodegenerative Diseases Research Group, Vall d'Hebron Research Institute (VHIR), Autonomous University of Barcelona, Barcelona, Spain

Synopsis

Keywords: Quantitative Imaging, Multi-ContrastImaging of the neuromelanin (NM) has recently developed as a relevant biomarker of Parkinson’s disease (PD). Here, we present a longitudinal, quantitative, multiparametric study on the AAV-hTyr rat model of PD with NM accumulation in the right substantia nigra. Our protocol allowed to obtain NM-sensitive image, as well as R1, R2* and qMT in a single session. Longitudinal acquisition on AAV-hTyr rats showed inverted U-shaped curve of NM-MRI contrast-to-noise ratio, suggesting NM accumulation followed by neurodegeneration. R1, R2*, MPF and motor symptoms support this hypothesis. Our work may help to understand the pathogenesis of this PD model and identify biomarkers.

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