Abstract #1263

Fast macromolecular proton fraction imaging based on spin-lock

Jian Hou¹, Yurui Qian¹, Baiyan Jiang², Xiang Fan³, Winnie Chiu-Wing Chu¹, Tiffany Y. So¹, and Weitian Chen¹

¹Department of Imaging and Radiology, The Chinese University of Hong Kong, Hong Kong SAR, Hong Kong, ²Illuminatio Medical Technology Limited, Hong Kong SAR, Hong Kong, ³Peking University Shenzhen Hospital, Shenzhen, China

Synopsis

Keywords: Quantitative Imaging, Magnetization transferMacromolecular proton fraction (MPF) represents the relative amount of semi-solid macromolecules involved in magnetization transfer with free water protons. In this work, we reported a novel MPF quantification method based on spin-lock for rapid MPF mapping. The total scan time for 3D brain MPF measurement can be achieved within five minutes. We demonstrated the proposed method via simulation, phantom and in vivo experiments.

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