Abstract #1264

Time-of-Day Analysis of Brain Sodium TSC Maps

Cameron E Nowikow^1,2, Paul Polak³, and Michael D Noseworthy^1,2,4,5

¹School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada, ²Imaging Research Centre, St. Joseph's Healthcare, Hamilton, ON, Canada, ³Department of Radiology, Children's Hospital Colorado Anschutz Medical Campus, Aurora, CO, United States, ⁴Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada, ⁵Department of Radiology, McMaster University, Hamilton, ON, Canada

Synopsis

Keywords: Quantitative Imaging, Non-Proton, Sodium, Variability, Brain, Circadian, Human

Previous investigations into brain sodium imaging have avoided the potential of variability due to circadian effects. Thus, in a pilot study we investigated whether time-of-day contributes to tissue sodium concentration (TSC) variance. Three TSC maps were acquired from 7 subjects, at three different times of day (8:00, 16:00, 22:00). Each TSC map was segmented into 10 ROIs before being analyzed using ANOVA with SNR and signal linewidth as added covariates. Time-of-day was a significant source of variance as was spectral linewidth. Between subject variance and SNR were not significant factors in the model.

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