Abstract #1265

Assessment of Rotator Cuff Muscle Fat and Fibrosis Using Quantitative UTE Magnetization Transfer Imaging and Modeling

Arya A Suprana^1,2, Qingbo Tang^1,3, Elisabeth Orozco^3,4, Hyungseok Jang¹, Saeed Jerban¹, Jiang Du^1,2,5, Yajun Ma¹, and Eric Y Chang^1,5

¹Department of Radiology, University of California, San Diego, La Jolla, CA, United States, ²Department of Bioengineering, University of California, San Diego, La Jolla, CA, United States, ³Research Service, VA San Diego Healthcare System, San Diego, CA, United States, ⁴Department of Orthopedic Surgery, University of California, San Diego, La Jolla, CA, United States, ⁵Radiology Service, Veterans Affairs San Diego Health Care System, San Diego, CA, United States

Synopsis

Keywords: Quantitative Imaging, MuscleAt present, there is a lack of available tools to non-invasively evaluate rotator cuff muscle fibrosis. Prior studies have suggested that magnetization transfer measurements may be useful for quantifying collagen when acquired with an ultrashort echo time technique. However, the increased presence of fat after muscle injury may confound these measurements. In this study, a rat model of chronic massive rotator cuff tearing was used with UTE-T1 and UTE-MT mapping without and with fat suppression to show that muscle collagen and fibrosis could be quantified.

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