Abstract #1266

Evaluation of tumor physiology after single-fraction irradiation in a mouse model of pancreatic ductal adenocarcinoma using mpMRI

Ramesh Paudyal¹, James Rusell¹, Eve LoCastro¹, Carl C. Lekaye¹, Joseph O. Deasy¹, John L. Humm¹, and Amita Shukla-Dave^1,2

¹Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ²Radiology, Memorial Sloan Kettering Cancer, New York, NY, United States

Synopsis

Keywords: Quantitative Imaging, PreclinicalPancreatic ductal adenocarcinoma (PDAC) is the leading cause of cancer deaths worldwide. Quantitative multiparametric magnetic resonance imaging (mpMRI) allows for measuring the tumor's physiological characteristics, such as cellularity and vascularity/permeability. This study aimed to evaluate tumor physiology using mpMRI after single-fraction irradiation in a mouse model. The results demonstrated the changes in the functional status of mpMRI metrics. They were validated with in vivo histology markers of tumor perfusion (Hoechst 33342) and tissue morphology (Hematoxylin and eosin staining).

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