Abstract #1268

Short single pulse optogenetic fMRI mapping of downstream targets in thalamo-cortical pathways

Linshan Xie^1,2, Xunda Wang^1,2, Teng Ma^1,2,3, Hang Zeng^1,2, Junjian Wen^1,2, Peng Cao³, Ed X. Wu^1,2,4, and Alex T.L. Leong^1,2

¹Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, ²Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China, ³Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, ⁴School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China

Synopsis

Keywords: fMRI (task based), fMRI (task based)Short single pulse stimulation is advantageous to map the downstream neural targets compared to pulse train stimulation because it can minimize the excessive neural synchronization and avoid numerous series of complex neural events. It is desirable for fMRI studies to investigate the properties of neural circuits via delivering single pulse stimulation. However, the subtle BOLD responses evoked by short stimuli are hard to detect due to the sensitivity issue. Here, we employed fMRI to examine the long-range downstream targets of the somatosensory thalamus with 10ms single pulse stimulation. A model-free fMRI analysis was utilized to visualize the spatiotemporal activity propagation.

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