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Abstract #1269

Somatosensory-evoked fMRI with chemogenetic modulation reflects behavioral normalization in hypersensitized mice

Won Beom Jung1,2, Soowon Lee3, Geun Ho Im1, Taeyi You1, Eunjoon Kim4,5, and Seong-Gi Kim1,6
1Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon, Korea, Republic of, 2Medical Imaging AI Research Center, Canon Medical Systems Korea, Seoul, Korea, Republic of, 3Graduate School of Medical Science and Engineering,, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea, Republic of, 4Department of Biological Sciences, Korea Advanced Institute for Science and Technology (KAIST), Daejeon, Korea, Republic of, 5Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS), Daejeon, Korea, Republic of, 6Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of

Synopsis

Keywords: fMRI (task based), AnimalsThe fMRI mapping with selective modulation of local neural population at the manipulated region is a powerful approach that can causally link circuit-specific interactions to behavioral performance. However, most fMRI studies combined with chemogenetics were conducted in the resting state, which is difficult to elucidate whether and how differences in functional activity by neuromodulation induce behavioral changes. Here, we demonstrated the effects of fMRI-guided focal chemogenetic modulation on both somatosensory-evoked network and its relevant behaviors in mice.

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