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Abstract #1272

Multi-echo, multi-contrast functional activation: validation of combined spin- and gradient-echo EPI in fMRI

Elizabeth G. Keeling1,2, Maurizio Bergamino1, Sudarshan Ragunathan1,3, C. Chad Quarles1,4, and Ashley M. Stokes1
1Barrow Neurological Institute, Phoenix, AZ, United States, 2Arizona State University, Tempe, AZ, United States, 3Hyperfine, Inc., Guilford, CT, United States, 4MD Anderson Cancer Center, Houston, TX, United States

Synopsis

Keywords: Data Acquisition, fMRI (task based), Neuro, multi-echo, multi-contrast, EPIStandard functional MRI (fMRI) suffers from susceptibility-induced dropout near air-tissue interfaces and is sensitive to larger vessels. Conversely, a combined spin- and gradient-echo (SAGE) acquisition can provide sensitivity to functional activation across macro- and microvascular scales with reduced signal dropout. Multi-echo analysis of SAGE-fMRI data was performed by using quantitative and relaxation-weighted T2* and T2. In a task-based experiment, SAGE relaxation-weighted analyses showed increased contrast- and temporal signal-to-noise ratios (CNR and tSNR, respectively), especially for microvascular analysis. SAGE-fMRI provides improvements over standard fMRI in image quality and robustness of functional activation, as well as inclusion of microvascular sensitivity.

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