Abstract #1279

Implantable Coils Enable High-Resolution Functional MRI in Awake Mice

David Hike¹, Xiaochen Liu¹, Zeping Xie^1,2, Bei Zhang¹, Wenchao Yang¹, Alyssa Murstein^1,3, Andy Liu^1,3, Daniel Glen⁴, Richard Reynolds⁴, and Xin Yu¹

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, ²School of Traditional Medicine, Southern China University, Guangzhou, China, ³Neuroscience, Boston University, Boston, MA, United States, ⁴NIMH, National Institutes of Health, Bethesda, MD, United States

Synopsis

Keywords: fMRI (task based), Preclinical, Implantable CoilThis study utilizes implantable RF coils affixed to mouse heads which are used as head fixation points to minimize motion and remove B₁-related artifacts due to motion-induced loading change during scanning. This method increases SNR significantly and enables high-resolution EPI-based functional imaging in awake mice at 14T, highlighting both cortical and subcortical activation following visual and whisker stimulation. Furthermore, this high-resolution awake mouse fMRI setup enables high sensitivity to map brain activation from subcortical nuclei and extends the detection of associated brain regions related to the stimulation.

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