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Abstract #1279

Implantable Coils Enable High-Resolution Functional MRI in Awake Mice

David Hike1, Xiaochen Liu1, Zeping Xie1,2, Bei Zhang1, Wenchao Yang1, Alyssa Murstein1,3, Andy Liu1,3, Daniel Glen4, Richard Reynolds4, and Xin Yu1
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, 2School of Traditional Medicine, Southern China University, Guangzhou, China, 3Neuroscience, Boston University, Boston, MA, United States, 4NIMH, National Institutes of Health, Bethesda, MD, United States

Synopsis

Keywords: fMRI (task based), Preclinical, Implantable CoilThis study utilizes implantable RF coils affixed to mouse heads which are used as head fixation points to minimize motion and remove B1-related artifacts due to motion-induced loading change during scanning. This method increases SNR significantly and enables high-resolution EPI-based functional imaging in awake mice at 14T, highlighting both cortical and subcortical activation following visual and whisker stimulation. Furthermore, this high-resolution awake mouse fMRI setup enables high sensitivity to map brain activation from subcortical nuclei and extends the detection of associated brain regions related to the stimulation.

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