Abstract #1280

En Route to Fine-Grained Neurosignatures in the Individual Brain: Evaluating Methodology to Boost Spatial Accuracy & Sensitivity of BOLD fMRI

Igor Fabian Tellez Ceja¹, Thomas Gladytz¹, Ludger Benedikt Starke¹, Karsten Tabelow², Thoralf Niendorf^1,3, and Henning Matthias Reimann¹

¹Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine, Berlin, Germany, ²Weierstrass Institute for Applied Analysis and Stochastics, Berlin, Germany, ³Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

Synopsis

Keywords: High-Field MRI, fMRI

In recent years, fMRI at ultrahigh magnetic field strengths (≥7T) has shifted from group analyses to probing neural processing in the individual brain. Identifying neurosignatures requires detection of BOLD effects with high sensitivity and spatial accuracy. Yet, it remains a challenge to enhance the sensitivity of fMRI for the BOLD effect without blurring the spatial details. Here, we assess the quality of the Gaussian, spatial adaptive non-local means (SANLM) and the adaptive weights smoothing (AWS) filters by employing a synthetic fMRI dataset as ground truth. AWS provides superior localization of the BOLD activations with high sensitivity at reasonable noise levels.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.