Keywords: fMRI, fMRI, cell-type specific optogentics; basal forebrainActivations of the basal forebrain (BF) were associated with arousal fluctuations1, and the regulation of the default model network2,3. However, it remains ambiguous how the cell-type specific BF neurons shape the behavioral performances. We developed an awake mouse fMRI setup with simultaneous cell-type specific optogenetic stimulations in BF. Combined with the anterograde tracing data4, we revealed weak structural-functional correspondence of BF neurons, and demonstrated the cell-type specific BF modulations shaped global functional network organizations supporting behavioral variability. Our results made great sense on the understanding the cerebral regulations and behaviors from BF neurons in a macroscopic whole-brain view.
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