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Abstract #1285

Diffusion weighted, intravoxel incoherent motion, diffusion kurtosis tensor MR imaging in chronic kidney disease: correlations with histology

Jie Zhu1, Jia-Yin Gao1, Pu-Yeh Wu2, and Yan Song1
1Beijing Hospital, Beijing, China, 2GE Healthcare, Beijing, China

Synopsis

Keywords: Data Analysis, Diffusion/other diffusion imaging techniquesNoninvasive, repeatable and accurate biomarkers to identify renal histological changes for tailoring treatment and evaluating renal prognosis are demanded. In this study, we aimed to compare and probe correlations of parameters derived from standard DWI and its extending models including IVIM, DTI, and DKTI with the pathological and functional alterations in CKD. We found that the corrected diffusion-related indices, including cortical and medullary D and MD, as well as medullary FA were superior to ADC, perfusion-related and kurtosis indices for evaluating alterations of renal pathology and function in CKD patients, and these metrics were also correlated with eGFR and Scr.

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