Abstract #1286

Magnetization-Prepared Golden-angle RAdial Sparse Parallel (MP-GRASP) MRI for Rapid Free-Breathing 3D T1 Mapping of Renal Allografts

Octavia Bane^1,2, Li Feng^1,2, Ding Xia^1,2, Haitham Al-Mubarak^1,2, Jordan Cuevas^1,2, Thangamani Muthukumar³, Jonathan Dyke⁴, Madhav Menon⁵, Samira Farouk⁶, Bachir Taouli^1,2, and Sara Lewis^1,2

¹Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Nephrology, Weill Cornell Medical College, New York, NY, United States, ⁴Citigroup Biomedical Imaging Center, Weill Cornell Medical College, New York, NY, United States, ⁵Nephrology, Yale School of Medicine, New Haven, CT, United States, ⁶Department of Medicine, Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

Synopsis

Keywords: Kidney, Quantitative Imaging, T1 mapping, cortex, medulla, transplantationThis work demonstrates rapid free-breathing 3D T1 mapping of the kidney using Magnetization-Prepared Golden-angle RAdial Sparse Parallel imaging (GraspT1). The accuracy and performance of GraspT1was prospectively compared with B1-corrected variable flip angle (VFA) T1 mapping in phantom and in 13 patients with renal transplant. In phantom, both GraspT1 and VFA enabled accurate T1 estimation compared to the gold standard. In patients, free-breathing 3D GraspT1 provided better spatial resolution for improved cortico-medullary differentiation compared to the VFA method, while achieving whole-kidney coverage and similar T1 quantification, at the expense of longer acquisition time.

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