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Abstract #1289

Highly Accelerated and High-resolution T2 Mapping in the Kidney Based on Echo Merging Plus k-t Undersampling with Reduced Refocusing Flip Angles

Hao Li1,2, Andrew Nicholas Priest2,3, Ines Horvat Menih 2, Anne Y Warren4, Sarah J Welsh5, Grant D Stewart6, Iosif A Mendichovszky3, Susan Francis7, and Ferdia A Gallagher2
1The Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China, 2Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 3Department of Radiology, CUH NHS Foundation Trust, Cambridge, United Kingdom, 4Department of Histopathology, CUH NHS Foundation Trust, Cambridge, United Kingdom, 5Department of Oncology, CUH NHS Foundation Trust, Cambridge, United Kingdom, 6Department of Surgery, CUH NHS Foundation Trust, Cambridge, United Kingdom, 7Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom

Synopsis

Keywords: Kidney, Quantitative ImagingWe developed a highly accelerated multi-echo spin-echo (MESE) method based on echo merging and k-t undersampling with reduced flip angles (TEMPURA), which can be used to either reduce the acquisition time or increase spatial resolution for multi-slice kidney T2 mapping. Compared with a standardized respiratory-gated MESE sequence, fast TEMPURA reduced the acquisition time from 3–5 minutes to one breath-hold (18 s) without degrading measurement accuracy or image quality. It also outperformed using k-t undersampling alone. High-resolution TEMPURA reduced the pixel size from 3×3 mm2 to 1×1 mm2 and greatly improved the visualization of detailed structures.

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