Abstract #1294

Renal impairment characterization of patients with systemic sclerosis by multi-parametric magnetic resonance imaging

Xinyu Tong¹, Huilin He², Zihan Ning³, Rui Shen³, Zuoxiang He¹, Xihai Zhao³, and Dong Xu²

¹School of Clinical Medicine, Tsinghua University, Beijing, China, ²Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, ³Center for Biomedical Imaging Research, Tsinghua University, Beijing, China

Synopsis

Keywords: Kidney, Kidney, systemic sclerosisRenal microstructure and functional impairment in systemic sclerosis were characterized using multi-parametric quantitative MR imaging including SAMURAI, DWI and BOLD sequences. The mean values of T1, RBF, aBAT, tBAT, ADC, T2* in renal cortex and volume of renal parenchyma were quantified. Compared to healthy volunteers, patients with systemic sclerosis had significantly lower mean RBF values in both sides of renal cortex. This study revealed that decline of RBF in systemic sclerosis may indicate the pathology of microvascular impairment of renal tissues.

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