Abstract #1295

Functional MRI to monitor disease progression in patients with rare kidney disease

Anna Caroli¹, Giulia Villa¹, Erica Daina², Paolo Brambilla³, Sara Gamba², Valentina Fanny Leone⁴, Camillo Carrara⁴, Paola Rizzo⁵, Marina Noris², Giuseppe Remuzzi⁶, and Andrea Remuzzi⁷

¹Bioengineering Department, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Ranica (BG), Italy, ²Department of rare diseases, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Ranica (BG), Italy, ³Unit of Radiology, ASST Papa Giovanni XXIII, Bergamo, Italy, ⁴Unit of Nephrology and Dialysis, ASST Papa Giovanni XXIII, Bergamo, Italy, ⁵Department of Molecular Medicine, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy, ⁶Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy, ⁷University of Bergamo, Bergamo, Italy

Synopsis

Keywords: Kidney, Quantitative ImagingThis study investigates the correlation between MRI and histologic and clinical findings in 7 patients with C3 glomerulopathy and immune complex–associated membranoproliferative glomerulonephritis, rare diseases denoted by poor prognosis and no specific therapies. Patients underwent repeated kidney MRI, biopsy, and laboratory testing. Kidney diffusivity and perfusion were assessed by diffusion-weighted and phase-contrast MRI. Laboratory and MRI parameters changed very differently from case to case over 1 year. Perfusion biomarkers significantly correlated with histological and clinical findings. Both perfusion and diffusion biomarkers correlated with the clinical evolution of the disease. Current findings highlight MRI potential to monitor kidney disease progression.

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