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Abstract #1298

A ray of light against age-related Neurodegenerative disease: A 31P Magnetisation Transfer MRS study

Elizabeth Jane Fear1, Frida Torkelsen2, Heidi A Baseler3, and Aneurin James Kennerley4
1Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy, 2Chemistry, University of York, York, United Kingdom, 3Psychology, University of York, York, United Kingdom, 4Sport and Exercise Science, Institute of Science, Manchester Metropolitan University, Manchester, United Kingdom

Synopsis

Keywords: Neurodegeneration, Magnetization transfer, 31PThrough combined theoretical Monte Carlo stimulation and practical 31P Magnetisation Transfer Magnetic Resonance Spectroscopy we quantify the effects of 670 nm photobiomodulation treatment on healthy aging brains. Mitochondrial function declines with age and many pathological processes of neurodegenerative diseases stem from this mitochondrial dysfunction when they fail to produce the necessary energy required. Therefore, an aging population coupled with associated increases in cases of neurological conditions amplifies the need to develop safe, inexpensive treatments to restore mitochondrial function and offer neuronal protection as we grow old. Evidence shows that non-invasive transcranial red/infrared photobiomodulation (PBM) therapy can offer such neuroprotective benefits.

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