Abstract #1299

Age-related alterations in soma and neurite fraction obtained from high-gradient diffusion MRI data across the lifespan

Hansol Lee¹, Hong-Hsi Lee¹, Laleh Eskandarian¹, Kyla Gaudet¹, Qiyuan Tian¹, Eva A. Krijnen^2,3, Eric C. Klawiter², and Susie Y. Huang¹

¹Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, ³MS Center Amsterdam, Anatomy and Neurosciences, Amsterdam Neuroscience, Amsterdam UMC location VUmc, Amsterdam, Netherlands

Synopsis

Keywords: Neurodegeneration, Aging

We studied alterations in soma and neurite signal fractions with age based on Soma And Neurite Density imaging (SANDI) in 43 healthy adults across the lifespan using multi-shell dMRI measurements acquired on the MGH Connectome scanner. We observed decreases in soma fraction with age in all cortical lobes, especially in the frontal lobe. The neurite fraction predominantly decreased with age in the genu of corpus callous. These results suggest a regionally selective aging effect on changes in compartmental composition within the brain, potentially reflecting alterations in microstructure associated with neurodegeneration.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.