Abstract #1300

Structural network integrity in limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC)

Mahir Tazwar¹, Arnold M Evia², Abdur Raquib Ridwan², David A Bennett², Julie A Schneider², and Konstantinos Arfanakis^1,2

¹Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, ²Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, United States

Synopsis

Keywords: Neurodegeneration, White Matter, LATE-NC, TDP-43, neuropathology, aging

Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is a common pathological finding in the brain of older adults, but its impact on structural network integrity remains unknown. In this work, we studied structural connectivity network abnormalities associated with LATE-NC using graph theory. Our results demonstrated that severity of LATE-NC was independently associated with weaker network integration and segregation, and increased vulnerability in a network of brain regions typically affected by LATE-NC.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.