Abstract #1303

Pronounced gender and lifestyle effects in the oxygen extraction fraction (OEF) of the ageing brain

Ana-Maria Oros-Peusquens¹, Luis Hau¹, Junghun Cho², Nora Bittner^3,4, Svenja Caspers^3,5, Yi Wang², and N. Jon Shah^1,6,7,8,9

¹INM-4, Research Centre Juelich, Juelich, Germany, ²Department of Radiology, Weill Cornell Medical College, New York, NY, United States, ³INM-1, Research Centre Juelich, Juelich, Germany, ⁴4Institute for Anatomy I, Medical Faculty & University Hospital Düsseldorf, Heinrich Heine University, Duesseldorf, Germany, ⁵Institute for Anatomy I, Medical Faculty & University Hospital Düsseldorf, Heinrich Heine University, Duesseldorf, Germany, ⁶RWTH Aachen University, Aachen, Germany, ⁷INM-11, JARA, Forschungszentrum Jülich, Juelich, Germany, ⁸JARA - BRAIN - Translational Medicine, Aachen, Germany, ⁹Department of Neurology, RWTH Aachen University, Aachen, Germany

Synopsis

Keywords: Neurodegeneration, Aging, oxygen extraction fraction, OEF, gender differences, menopause

Regionally-resolved oxygen extraction fraction was investigated in an elderly cohort. OEF was obtained from a single 3D mGRE scan using a novel integrated model of QSM phase signal and quantitative blood oxygenation level dependent magnitude signal. Whereas age showed little influence on this metabolic parameter, a pronounced gender effect was observed. A lifestyle index reflecting physical and social activity as well as alcohol and nicotine consumption showed strong correlations with OEF. Venous blood volume fraction and tissue R2*, but not tissue QSM, also reflected lifestyle influence, showing that brain age is more than number of years.

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