Abstract #1304

Cardiovascular and cerebrovascular health in 70-year-olds: a population-based ASL study

Mathijs B.J. Dijsselhof^1,2, Sarah-Naomi James³, Luigi Lorenzini^1,2, Lyduine Collij^1,2, David L. Thomas^4,5, Catherine Scott⁵, Emily Manning⁵, Tamás I. Józsa^1,2, Dave Cash⁵, Insight 46 study team⁵, Carole Sudre³, Alun D. Hughes³, Marcus Richards³, Frederik Barkhof^1,2,6, Jonathan Schott⁵, Jan Petr^1,2,7, and Henk J.M.M. Mutsaerts^1,2

¹Radiology & Nuclear Medicine, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam, Netherlands, ²Amsterdam Neuroscience, Brain Imaging, Amsterdam, Netherlands, ³MRC Unit of Lifelong Health at Ageing at UCL, University College London, London, United Kingdom, ⁴Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, London, United Kingdom, ⁵Dementia Research Centre, UCL Queen Square Institute of Neurology, London, United Kingdom, ⁶Queen Square Institute of Neurology and Centre for Medical Image Computing, University College London, London, United Kingdom, ⁷Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany

Synopsis

Keywords: Neurodegeneration, Arterial spin labelling

While mid-life cardiovascular pathology may lead to late-life cognitive decline, our understanding of the role of cerebrovascular health as an intermediate biomarker is limited. We explored the association between cardiovascular health biomarkers and cross-sectional and longitudinal cerebrovascular health assessed by ASL MRI in Insight46, a well-characterised cognitively normal population-based sample.

We found several cross-sectional and longitudinal associations between blood pressure and CBF. These findings suggest that the effects of BP on cerebrovascular health can be imaged with ASL perfusion MRI, possibly offering opportunities to prevent or intervene before cognitive decline sets in.

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