Abstract #1305

Medial Temporal Brain Stiffness Predicts Cognition Decline in Aging and Alzheimer's Disease

KowsalyaDevi Pavuluri¹, John Huston III¹, Richard L. Ehman¹, Armando Manduca^1,2, Prashanthi Vemuri¹, Clifford R. Jack Jr¹, Matthew L. Senjem³, and Matthew C. Murphy¹

¹Department of Radiology, Mayo Clinic, Rochester, MN, United States, ²Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochetser, MN, United States, ³Department of Information Technology, Mayo Clinic, Rochester, MN, United States

Synopsis

Keywords: Neurodegeneration, Aging, Stiffness and Cognition

Aging is associated with neurodegeneration, cognitive function decline, and increased risk of dementia. Objective methods for the longitudinal prediction of cognitive trajectories are needed for design of comprehensive prevention strategies. We tested the hypothesis that measurements of brain mechanical properties will complement existing biomarkers in predicting future cognitive decline. Using linear mixed effect modelling, we evaluated the role of baseline medial temporal stiffness in predicting future cognitive function in participants along the Alzheimer’s disease spectrum.

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