Abstract #1308

Differences in age trajectories of intracortical myelin across lifespan measured by MTR and T1w/T2w

Yu Veronica Sui¹, Ryn Flaherty¹, Arjun V. Masurkar^2,3,4, Thomas Wisniewski^2,4,5,6, Henry Rusinek^1,5, and Mariana Lazar¹

¹Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States, ²Department of Neurology, New York University Grossman School of Medicine, New York, NY, United States, ³Department of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, NY, United States, ⁴Neuroscience Institute, New York University Grossman School of Medicine, New York, NY, United States, ⁵Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, United States, ⁶Department of Pathology, New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Neurodegeneration, AgingIn a large cohort of healthy participants (N=349, age range 18-90 years), we characterized intracortical myelin lifespan trajectories using two commonly used myelin proxies, magnetization transfer ratio (MTR) and T1w/T2w, combined with a surface-based image processing method. We showed that both measures exhibit an inverted-U shape trajectory for most cortical regions, with T1w/T2w values peaking later than MTR. A smoothed spline fitting of the trajectories allowed further delineation of onset decline age, a potential aging milestone. Frontal and temporal lobe regions showed consistently later peak ages than parietal and sensory motor regions across MRI metrics and curve fitting methods.

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