Abstract #1309

Age-related alterations of hippocampal microstructure quantified using diffusion MRI in a unfolded hippocampal space

Yixin Ma^1,2, Hansol Lee^1,2, Qiyaun Tian^1,2, Susie Y Huang^1,2, and Hong-Hsi Lee^1,2

¹Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Radiology, Harvard Medical School, Boston, MA, United States

Synopsis

Keywords: Neurodegeneration, MicrostructureThe hippocampus plays an important role in cognition and memory. Microstructural alterations can happen in specific sub-regions within the hippocampus in normal aging. Applying more advanced diffusion models and pinpointing changes in specific locations in the hippocampus, though challenging, may offer greater insight into subfield-specific neurodegeneration. Here, we applied advanced biophysical models of dMRI and correlated tissue parameters with age across the unfolded hippocampal coordinates in 43 healthy adults covering a wide age span.

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