Abstract #1311

White matter changes underlying cortical changes across the lifespan

Kurt G Schilling¹, Victor Nozais², Francois Rheault³, Derek Archer⁴, Muwei Li¹, Leon Y Cai⁵, Flavio Dell'Acqua⁶, John C Gore¹, and Bennett A Landman⁵

¹Vanderbilt University Medical Center, Nashville, TN, United States, ²Institut des Maladies Neurodégénératives-UMR, Bordeaux, France, ³Sherbrooke University, Sherbrooke, QC, Canada, ⁴Vanderbilt University School of Medicine, Nashville, TN, United States, ⁵Vanderbilt University, Nashville, TN, United States, ⁶King's College London, London, United Kingdom

Synopsis

Keywords: White Matter, AgingBrain functions are a property of the interaction between brain areas. While much is known about cortical structure and the structural connections in the white matter, the interaction between the cortex and white matter is underexplored. Here, we aim to investigate and characterize the relationship between white and cortical changes across the lifespan. We use the functionnectome framework to associate white matter to morphological features of the cortex. Biologically, this white matter influences (or is influenced by) these cortical changes.

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