Keywords: White Matter, MicrostructureThis study compared age-related differences in white matter morphology and microstructure across ten major tracts of the human brain using diffusion data from 535 participants of the Human Connectome Project in Aging. The results are additionally assessed for agreement with retrogenesis predictions of white matter decline in normal aging. While whole-brain relationships between morphometry and white matter integrity were identified, high variability was also observed between tracts. While our data do not fully support retrogenesis models, we demonstrate patterns that may provide partial support, and highlight the need for tract-specific studies of morphological-microstructural interactions in the aging white matter.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords