Abstract #1314

Carotid wall shear stress and wall thickness in patients with familial hypercholesterolemia and their healthy siblings

Eva S. Peper^1,2, Dieuwertje Alblas³, Renske Merton⁴, Sibbeliene E. van den Bosch⁵, Anne Spakman⁴, Bram F. Coolen⁶, Gustav J. Strijkers⁶, Aart J. Nederveen⁴, Albert Wiegman⁵, Jelmer M. Wolterink³, Barbara A. Hutten⁷, and Pim van Ooij⁴

¹Bern University Hospital, University of Bern, Bern, Switzerland, ²Translation Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland, ³Department of Applied Mathematics, Technical Medical Center, University of Twente, Enschede, Netherlands, ⁴Department of Radiology and Nuclear Medicine, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, location AMC, Amsterdam, Netherlands, ⁵Department of Pediatrics, Amsterdam University Medical Center, location AMC, Amsterdam, Netherlands, ⁶Department of Biomedical Engineering & Physics, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, location AMC, Amsterdam, Netherlands, ⁷Department of Epidemiology and Data Science, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, location AMC, Amsterdam, Netherlands

Synopsis

Keywords: Flow, Velocity & Flow, vessel wall, carotids, familial hypercholesterolemiaFamilial hypercholesterolemia (FH) leads to premature atherosclerosis. In this study we use 4D flow and 3D black blood (BB) MRI to investigate carotid artery wall shear stress (WSS) and wall thickness (WT) 3D maps and their relation, in FH patients on lifelong statin prescriptions and their unaffected siblings (n=234). We applied machine learning segmentation technology and 3D statistical analysis methods and found that ensemble-averaged carotid WSS and WT maps were highly similar between the groups. However, the 3D carotid correlation coefficient maps showed lower agreement between WT and WSS in patients, suggesting abnormal wall remodeling processes compared to the siblings.

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