Abstract #1315

Predicting carotid plaque vulnerability by macrophage-targeted nanocluster-enhanced high-resolution vessel wall imaging

Yan Gong¹, Menglin Wu², Dingwei Fu³, Yu Guo⁴, Xiudi Lu⁵, Ying Zou⁶, Xiang Zhang¹, Jinxia Zhu⁷, Xianchang Zhang⁷, Xue Li², and Shuang Xia⁵

¹Department of Radiology, Tianjin Nankai Hospital, Tianjin, China, ²Department of Radiology, Second Hospital of Tianjin Medical University, Tianjin, China, ³Department of Radiology, First Central Clinical College, Tianjin Medical University, Tianjin, China, ⁴Department of Radiology, Medical Imaging Institute of Tianjin, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China, ⁵Department of Radiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin，China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China, ⁶First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin，China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China, ⁷MR Collaboration, Siemens Healthcare Ltd., Beijing, China

Synopsis

Keywords: Vessel Wall, Atherosclerosis, macrophageIschemic stroke can be attributed to the sudden rupture of high-risk atherosclerotic plaques. Therefore, identifying vulnerable plaque is essential for preventing acute vascular events. Increasing evidence has established that macrophages play a vital role in the pathogenesis of atherosclerosis. Using the black-blood technique, an imaging approach that suppresses blood signals to highlight the arterial wall, and a macrophage-targeted contrast agent, plaque vulnerability could be quantitatively assessed for the macrophage burden. This in vivo animal study non-invasively evaluated the plaque vulnerability, which may provide information on the clinical risk stratification.

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