Abstract #1318

Sex differences between total cerebral blood flow and age-related changes in the brain using 4D flow MRI

Alma Spahic¹, Grant S. Roberts¹, Anthony Peret², Rebecca L. Koscik³, Erin Jonaitis^3,4, Carson A. Hoffman², Leonardo A. Rivera-Rivera^1,4, Karly A. Cody⁴, Howard A. Rowley², Sterling C. Johnson^3,4,5, Oliver Wieben^1,2, Kevin M. Johnson^1,2, and Laura Eisenmenger²

¹Medical Physics, University of Wisconsin- Madison, Madison, WI, United States, ²Radiology, University of Wisconsin- Madison, Madison, WI, United States, ³Wisconsin Alzheimer's Institute, University of Wisconsin- Madison, Madison, WI, United States, ⁴Wisconsin Alzheimer's Disease Research Center, University of Wisconsin- Madison, Madison, WI, United States, ⁵Geriatric Research Education and Clinical Center, William S. Middleton Memorial Veterans Hospital, Madison, WI, United States

Synopsis

Keywords: Flow, AgingVascular disease is strongly associated with Alzheimer’s disease. Therefore, it is important to establish normative cerebrovascular changes in aging populations. In this study, we assess sex-specific, age-related changes in total cerebral blood flow (tCBF) and total parenchymal volume in 754 cognitively healthy, older adults. We further investigate whether the same changes are observed in flow normalized by total parenchymal volume. We found (1) significant decrease in tCBF and total parenchymal volume with age in both sexes, (2) no correlation between age and normalized flow in male subjects, and (3) significant decrease in normalized flow with age in female subjects.

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