Abstract #1336

Dynamic contrast-enhanced MRI-based interstitial fluid pressure model in evaluation of nasopharyngeal carcinoma

Guixiao Xu¹, Chuanmiao Xie¹, Hui Li¹, Yun He¹, Liangru Ke¹, Haibin Liu¹, Liyun Zheng², and Yongming Dai³

¹Department of Radiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China, ²Shenzhen United Imaging Research Institute of Innovative Medical Equipment, Shenzhen, China, ³MR Collaboration, Central Research Institute, United Imaging Healthcare, Shanghai, China

Synopsis

Keywords: Head & Neck/ENT, Head & Neck/ENT

Nasopharyngeal carcinoma is cancer arising from the nasopharynx epithelium. The most widely researched etiological factor for nasopharyngeal carcinoma is the Epstein-Barr virus (EBV) infection. Elevated interstitial fluid pressure (IFP) is a significant biomarker for assessing head and neck malignant tumors. This study aimed to use the non-invasive dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)-based IFP model to evaluate nasopharyngeal carcinoma and distinguish the differences between nasopharyngeal carcinoma patients with low and high EBV-infected levels. As a result, the non-invasive DCE-MRI-based IFP model could be used to evaluate nasopharyngeal carcinoma and differentiate patients with high- and low-level plasma EBV DNA.

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