Abstract #1337

Application of IVIM, DKI, FROC and CTRW in vascular normalization induced by recombinant human endostatin in nasopharyngeal carcinoma.

Lixuan Huang¹, Hao Ren², Zongxiang Yang¹, Yao Hu¹, Huiting Zhang³, and Liling Long¹

¹The First Affliated Hospital of Guangxi Medical University, Nanning, China, ²Guangxi Medical University Kaiyuan Langdong Hospital, Nanning, China, ³MR Scientific Marketing, Siemens Healthineers Ltd., Wuhan, China

Synopsis

Keywords: Cancer, Diffusion/other diffusion imaging techniquesThis study explored the vascular normalization induced by recombinant human endostatin (RHES) in nasopharyngeal carcinoma (NPC) based on IVIM, DKI, FROC and CTRW. Results showed that the DKI_D, CTRW_alpha, and FROC_D had a significant difference between prior-treatment and Day 5 in RHES group, FROC_mu in Day 5 and CTRW_alpha in post-treatment were statistically significant in two groups, and DKI_K with decreased trend with the progress of RHES + IC treatment. These results suggest that the four diffusion models can detect the noninvasively monitor the vascular normalization induced by RHES in NPC.

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