Abstract #1342

Quantitative ΔR1 and PK Mapping Supports Tumor Habitat Delineation and Anti-Angiogenic Response Prediction of Vestibular Schwannoma

Xiaoping Zhu¹, Daniel Lewis^2,3,4, Ka-Loh Li¹, William Lloyd¹, Mueez Waqar^2,3,5, Ibrahim Djoukhadar^3,6, David J Coope^2,3,4, Andrew T King^2,3, Timothy Cootes¹, and Alan Jackson¹

¹DIIDS, University of Manchester, Manchester, United Kingdom, ²Dept. of Neurosurgery, Manchester Academic Health Science Centre, Manchester Academic Health Science Centre, Salford, United Kingdom, ³Geoffrey Jefferson Brain Research Centre, University of Manchester, Salford, United Kingdom, ⁴Division of Neuroscience and Experimental Psychology, University of Manchester, Manchester, United Kingdom, ⁵Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom, ⁶Dept. of Neuroradiology, Manchester Academic Health Science Centre, Manchester, United Kingdom

Synopsis

Keywords: Head & Neck/ENT, TumorIn this study we sought to undertake histogram and habitat analyses of tumoural DCE-MRI derived microvascular kinetic parameters and quantitative relaxation rate changes (ΔqR1) in patients with sporadic and neurofibromatosis type 2 (NF2) related vestibular schwannoma (VS). We demonstrate that within imaged VS tumours there is considerable intratumoural heterogeneity in DCE-MRI derived microvascular metrics and ΔqR1, with distinct intratumoural regions or habitats displaying high K^trans, v_p and ΔqR1 values respectively. We furthermore demonstrate within a cohort of NF2-related VS undergoing anti-angiogenic (bevacizumab) therapy that both pre-treatment K^trans and ΔqR1 are predictive of later tumour volumetric response at 90 days post-treatment.

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