Keywords: Head & Neck/ENT, TumorIn this study we sought to undertake histogram and habitat analyses of tumoural DCE-MRI derived microvascular kinetic parameters and quantitative relaxation rate changes (ΔqR1) in patients with sporadic and neurofibromatosis type 2 (NF2) related vestibular schwannoma (VS). We demonstrate that within imaged VS tumours there is considerable intratumoural heterogeneity in DCE-MRI derived microvascular metrics and ΔqR1, with distinct intratumoural regions or habitats displaying high Ktrans, vp and ΔqR1 values respectively. We furthermore demonstrate within a cohort of NF2-related VS undergoing anti-angiogenic (bevacizumab) therapy that both pre-treatment Ktrans and ΔqR1 are predictive of later tumour volumetric response at 90 days post-treatment.
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