Abstract #1344

Optimisation of an MRI protocol to assess the effects of noise exposure on the auditory pathway

Rebecca Susan Dewey^1,2,3, Hannah Guest^4,5, Rebecca E Millman^4,5, Garreth Prendergast^4,5, Christopher J Plack^4,5,6, and Susan T Francis¹

¹Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, ²National Institute for Health and Care Research (NIHR) Nottingham Biomedical Research Centre, Nottingham, United Kingdom, ³Hearing Sciences, Division of Mental Health and Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom, ⁴Manchester Centre for Audiology and Deafness (ManCAD), University of Manchester, Manchester, United Kingdom, ⁵National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, ⁶Department of Psychology, Lancaster University, Lancaster, United Kingdom

Synopsis

Keywords: Head & Neck/ENT, Nerves, Neurography, diffusion, DTIRecent findings suggest that noise exposure can cause substantial damage to the auditory nerve, without damage to the sensory hair cells or loss of threshold sensitivity. It is unclear which physiological measures are most sensitive to neural damage. Here, a comprehensive MRI protocol (neurography, high-resolution DTI of the auditory nerve and brain, morphometry, T₁-myelination mapping, and resting-state functional connectivity) to study the ascending auditory pathway (auditory nerve, auditory brainstem, and cortex) is described. 200 participants will be recruited with varying noise exposure levels, with the aim of identifying diagnostic tests indicative of future hearing loss.

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