Abstract #1347

Dose finding and sequence tailoring in sentinel lymph node detection of tongue cancer using superparagmagnetic iron-oxide particles

Gijs Heldens¹, Daphne Driessen², Tim Dijkema³, Anne Arens³, Patrik Zámecnik³, Sjoert Pegge³, Willem Weijs⁴, Adriana van Engen-van Grunsven⁵, Robert Takes¹, Johannes Kaanders², and Tom Scheenen³

¹Department of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, Netherlands, ²Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, Netherlands, ³Department of Medical Imaging, Radboud University Medical Center, Nijmegen, Netherlands, ⁴Department of Oral- and Maxillofacial Surgery and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, Netherlands, ⁵Department of Pathology, Radboud University Medical Center, Nijmegen, Netherlands

Synopsis

Keywords: Cancer, Head & Neck/ENTTo clarify the amount, timing and optimal pulse sequence settings of using interstitial superparamagnetic iron oxide particles (SPIO) as a contrast medium to detect sentinel lymph nodes in head and neck radiology, we injected SPIO peritumorally in six patients with early-stage oral squamous cell carcinoma. Anatomical and T2*-weighted MR images were acquired, and dose was altered after every two patients. Images with different computed echo times were created to determine the signal attenuation effect of SPIO on the sentinel lymph nodes.

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