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Abstract #1349

Decoding the phase-cycled bSSFP signal for maximized parameter quantification - T1, T2, proton density and magnetic field inhomogeneity

Nils Marc Joel Plähn1, Adèle Mackowiak2, Berk Açikgöz3, Eva Peper3, Giulia Rossi2, and Jessica Bastiaansen3
1Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern Universit, Bern, Switzerland, 2Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 3Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

Synopsis

Keywords: Relaxometry, Data Analysis, phase-cycled bSSFP, T1-quantification, T2-quantification, B0 quantification, proton-density quantification, multi-parameter quantificationA novel analytical method for off-resonance encoded parameter quantification of voxel-wise phase-cycled bSSFP signal profiles was developed. The approach conserves both magnitude and phase information in a complete, linearized, and compact way. A framework for ultra-rapid and simultaneous $$$T_1$$$, $$$T_2$$$, $$$B_0$$$ inhomogeneity and proton density quantification were developed. The approach was validated in simulations, phantom and in vivo knee experiments and compared with gold-standard reference measurements when available. Simulations and experiments validated the proposed method for multi-parameter quantification with high accuracy and precision, providing the first step towards novel analytical quantification possibilities with phase-cycled bSSFP.

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