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Abstract #1350

Rapid PD, T2, and T2* Mapping with 2in1-RARE-EPI and Model-Based Reconstruction in Multiple Sclerosis

Jose Raul Velasquez Vides1, Carl J. J. Herrmann1,2, Ludger Starke1,3, Hampus Olsson1, and Thoralf Niendorf1,4
1Berlin Ultrahigh Field Facility (B.U.F.F), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 2Department of Physics, Humboldt University of Berlin, Berlin, Germany, 3Digital Health - Machine Learning Research Group, Digital Health Center, Hasso Plattner Institute, University of Potsdam, Potsdam, Germany, 4Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

Synopsis

Keywords: Relaxometry, Multiple Sclerosis

One obstacle of established quantitative resonance imaging methods is the excessive scan time. This study examines the use of radially-sampled 2in1-RARE-EPI in conjunction with model-based reconstruction methods for accelerated and simultaneous PD, T2, and $$$T_{2}^{*}$$$ mapping. We demonstrate that this approach facilitates a substantial decrease in acquisition time (01:40 vs. 07:12 min) of 2in1-RARE-EPI without impairing the quality of the parametric maps. Our patient data demonstrate the applicability of model-based reconstructed 2in1-RARE-EPI for T2 and $$$T_{2}^{*}$$$ mapping of multiple sclerosis lesions.

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