Abstract #1353

Oxygen-enhanced and glucose-enhanced MRI for dual mapping of hypoxia and glucose uptake in tumours at high spatial resolution

Ben Dickie^1,2, Thomas Kisby³, Emily Rowling⁴, Julius Chung⁵, Mohammad Babur⁴, Lidan Christie¹, Tao Jin⁵, Kostas Kostarelos^3,6, Kaye Williams⁴, and James O'Connor⁷

¹Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK, Manchester, United Kingdom, ²Geoffrey Jefferson Brain Research Centre, University of Manchester, Manchester Academic Health Science Centre, UK, Manchester, United Kingdom, ³Nanomedicine Lab, Faculty of Biology, Medicine and Health and National Graphene Institute, University of Manchester, UK, Manchester, United Kingdom, ⁴Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK, Manchester, United Kingdom, ⁵Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA, Pittsburgh, PA, United States, ⁶Catalan Institute of Nanoscience and Nanotechnology (ICN2), UAB Campus Bellaterra, Barcelona, Spain, Barcelona, Spain, ⁷Division of Cancer Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK, Manchester, United Kingdom

Synopsis

Keywords: Multi-Contrast, CancerWe have developed a non-invasive imaging protocol for dual assessment of hypoxia and glucose uptake in tumours using oxygen-enhanced MRI and glucoCESL MRI, and test feasibility in GL261 glioblastoma and MOC2 head and neck cancer mouse models. GL261 tumours had a lower non-perfused fraction (p = 0.0015), a trend to higher glucose enhancing fraction (p = 0.07) and a smaller hypoxic glucose refractory fraction (p= 0.021). The normoxic glucose enhancing fraction was significantly larger than the normoxic glucose refractory fraction (p < 0.0001) in both models. These imaging tools will be used to assess the effects of hypoxia modifying drugs.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.