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Abstract #1356

FibraVasc: towards ex vivo MRI mapping of cerebral vascular territories, application to the vascularization of deep white matter bundles

Simon Legeay1, Mykyta Smirnov2, Maëlig Chauvel1, Bastien Herlin1, Laurent Barantin2,3, Ivy Uszynski1, Igor Lima Maldonado2,3, Christophe Destrieux2,3, and Cyril Poupon1
1BAOBAB, NeuroSpin, Université Paris-Saclay, CNRS, CEA, Gif-sur-Yvette, France, 2UMR 1253, iBrain, Université de Tours, Inserm, Tours, France, 3CHRU de Tours, Tours, France

Synopsis

Keywords: Relaxometry, Ex-Vivo Applications, Quantitative ImagingThe arterial distribution territories of the brain remain poorly characterized and are of major importance for treating ischemic strokes. We propose a new quantitative MRI approach for ex vivo mapping of vascular territories using paramagnetic gelatin injection into cerebral arteries to enhance MRI contrast at the gelatin level. This method was applied on one healthy human brain injected into the middle cerebral artery and accurately quantified the volume fraction of blood using a dedicated protocol and a modeling of the injected tissue signal. We projected the resulting mapping along the deep white matter fiber bundles.

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Keywords