Abstract #1357
In-vivo imaging of the human thalamus: a comprehensive evaluation of structural imaging approaches for thalamic nuclei differentiation at 7T
Cristina Sainz Martinez1,2, José P. Marques3, Gabriele Bonanno4,5,6, Tom Hilbert4,7,8, Constantin Tuleasca8,9,10, Meritxell Bach Cuadra2,7, and João Jorge1
1CSEM - Swiss Center for Electronics and Microtechnology, Bern, Switzerland, 2CIBM Center for Biomedical Imaging, Lausanne, Switzerland, 3Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, Netherlands, 4Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Bern, Switzerland, 5Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine (SITEM), Bern, Switzerland, 6Magnetic Resonance Methodology, Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland, 7Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 8Signal Processing Laboratory 5 (LTS-5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 9Department of Clinical Neurosciences, Neurosurgery Service and Gamma Knife Center, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland, 10Faculty of Biology and Medicine, University of Lausanne (UNIL), Lausanne, Switzerland
Synopsis
Keywords: Multi-Contrast, High-Field MRI, Thalamus, Nuclei, 7 Tesla, QSMThe ability to non-invasively image the thalamus and its different nuclei would be highly valuable to neuroscience and neuroradiology, but has remained challenging. Here, we initiated a comprehensive practical review of recent thalamic imaging approaches at 7 Tesla, based on T1, T2, T2* and susceptibility properties. These were all acquired on the same in-vivo brain, to avoid anatomical variability confounds. The images were qualitatively compared to histological atlases. Upon systematic assessment, QSM and GM/WM-optimized MP2RAGE proved the most valuable to differentiate specific nuclei. To our knowledge, this is the most comprehensive evaluation to date of thalamic imaging modalities at 7T.
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