Abstract #1366

The respective contribution of cell swelling and changes in hydrated water molecules to T2 changes due to changes in membrane potential

Seong-min Kim¹, Kyeongseon Min², Jung Seung Lee^1,3, and Jang-Yeon Park^1,3

¹Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of, ²Laboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, ³Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Korea, Republic of

Synopsis

Keywords: Contrast Mechanisms, Challenges, cell scan, qMR, ADC, T2, PSROur group recently reported a method for direct imaging of neuronal activity (DIANA), suggesting that its contrast mechanism is T₂ changes due to changes in membrane potential during neuronal activation, which accompanies cell swelling and changes in hydrating water modlecules of the cell membrane. In this study, by measuring apparent-diffusion-coefficient (ADC) and pool-size-ratio (PSR) versus T₂, respectively, we verified the respective contribution of cell swelling and changes in hydrating water modlecules to T₂ changes when only osmotic pressure or membrane potential was altered in T-lymphocyte cells in vitro.

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