Abstract #1383

Progressive cortical cerebrovascular reactivity reduction occurs in Parkinson's disease: a longitudinal study

Hongwei Li¹, Jian Wang^2,3, Jia Jia⁴, Xiali Shao², He Wang^1,5,6, and Lirong Jin⁴

¹Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, ²Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China, ³Department of Radiology, Zhongshan Hospital, Fudan University (Xiamen Branch), Xiamen, China, ⁴Department of Neurology, Zhongshan Hospital, Fudan Universit, Shanghai, China, ⁵Human Phenome Institute, Fudan University, Shanghai, China, ⁶Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China

Synopsis

Keywords: Parkinson's Disease, fMRI (resting state), cerebrovascular reactivityIncreasing evidence showed subtle cerebrovascular reactivity (CVR) impairment in neurodegenerative disease. In the longitudinal study herein, we aimed to investigate regional CVR changes in the patients with Parkinson’s disease (PD) at baseline and 2 years follow up, and CVR was derived from resting state fmri scans. PD patients showed significantly reduced CVR in the left inferior occipital gyrus and right superior temporal cortex. In addition, the reduction of CVR may associate with executive function deficits. Our results also showed that there was a tendency for functional connectivity to be weakened from posterior to anterior with the progression of the disease.

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