Abstract #1384

Therapy of Parkinson’s Disease Related Motor and Cognitive Decline with Deep Brain Stimulation of Nucleus Accumbens

Ting-Chieh Chen¹, Ssu-Ju Li¹, Kai-Yun Chen², Yu-Chun Lo², Yi-Chen Lin¹, Ching-Wen Chang¹, Yao-Wen Liang¹, Tsai-Yu Cho¹, Mu-Hua Wang¹, Sheng-Huang Lin^3,4, and You-Yin Chen^1,2

¹Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan, ²PhD Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan, ³Department of Neurology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan, ⁴Department of Neurology, School of Medicine, Tzu Chi University, Hualien, Taiwan

Synopsis

Keywords: Parkinson's Disease, Parkinson's DiseaseThe progression of Parkinson′s disease (PD) is associated with mitochondrial dysfunction, and deep brain stimulation (DBS) of the nucleus accumbens (NAc) was found to enhance mitochondrial function. Therefore, the presented study aimed to explore the therapeutic effects of NAc-DBS on PD. In this study, the NAc-DBS treatment, behavioral tests, brain magnetic resonance imaging analysis, and mitochondrial respiratory assay were conducted on the MitoPark PD mouse model. After NAc-DBS, the PD mouse model showed improvements in motor and cognitive functions with increased functional connectivity and promoted aerobic metabolism in the dopaminergic (DA) pathways.

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