Keywords: Parkinson's Disease, Quantitative Susceptibility mapping
The purpose of this study was to employ QSM and OEF maps to quantitatively measure iron content and oxygen metabolism levels in deep gray matter of the Parkinson’ s disease brains in different stages and explore their relationship with clinical features. Iron accumulation in SN, RN and GP significantly increased with the progression of PD severity. In contrast, OEF in CAU, PT, and DN elevated in early PD and then gradually decreased with worsening symptoms, indicating a different spatiotemporal pattern. These findings may facilitate to understand the neurobiological mechanisms in PD progression and offered complementary indicators for diagnosis and prediction.
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