Abstract #1387

Enzyme Delivery to the Putamen in Parkinson’s Disease Patients by MR-Guided Focused Ultrasound

Yuexi Huang¹, Ying Meng^2,3, Christopher B. Pople³, Allison Bethune³, Ryan M. Jones¹, Agessandro Abrahao^3,4, Clement Hamani^2,3, Suneil K. Kalia^5,6, Lorraine V. Kalia^5,7, Nir Lipsman^2,3, and Kullervo Hynynen^1,8,9

¹Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ²Division of Neurosurgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ³Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, ON, Canada, ⁴Department of Medicine, University of Toronto, Toronto, ON, Canada, ⁵Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁶Division of Neurosurgery, Toronto Western Hospital, Toronto, ON, Canada, ⁷Division of Neurology, Toronto Western Hospital, Toronto, ON, Canada, ⁸Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁹Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: Parkinson's Disease, Focused UltrasoundThe phase I clinical trial demonstrated the successful application of microbubble-assisted MR-guided Focused Ultrasound for blood-brain barrier (BBB) opening in the putamen to facilitate biweekly therapeutic drug delivery in patients with Parkinson's disease. BBB permeability within the targeted putamen was elevated successfully in all treatments, as revealed by Gd-enhanced T1-weighted MRI immediately post treatment. No contrast enhancement was observed in the treated putamen on MR imaging scans acquired one day following each treatment session, indicating closure of the BBB. FDG-PET revealed a reduction of glucose metabolism of the treated putamen relative to the contralateral putamen in all patients.

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