Keywords: Parkinson's Disease, Relaxometry, IronIron has an important role in Parkinson’s disease (PD) pathophysiology. However, it is still uncertain how iron accumulates within the nigrostriatal circuit along with PD progression. Here we assessed iron content from early to moderate PD stages using R2* relaxometry, and histologically using a macaque MPTP (1-metil-4-fenil6-tetrahidropiridina) model. Our analyses revealed that in both human PD and MPTP model, iron accumulates progressively within SNpc during early stages , reaching a plateau before moderate PD. Meanwhile, iron followed a V-shaped progression in the striatum. These results will contribute to improve our understanding of nigrostriatal vulnerability and the course of neurodegeneration in PD.
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