Abstract #1390

A 3D nigrosome atlas based on multi-modal histology and multi-parametric quantitative MRI

Malte Brammerloh¹, Evgeniya Kirilina^1,2, Anneke Alkemade³, Pierre-Louis Bazin^1,3, Caroline Jantzen¹, Sara Schaumberg¹, Carsten Jäger^1,4, Andreas Herrler⁵, Kerrin J. Pine¹, Markus Morawski^1,4, Birte Forstmann³, and Nikolaus Weiskopf^1,6

¹Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ²Center for Cognitive Neuroscience Berlin, Freie Universität Berlin, Berlin, Germany, ³Integrative Model-based Cognitive Neuroscience Research Unit, University of Amsterdam, Amsterdam, Netherlands, ⁴Paul Flechsig Institute - Center of Neuropathology and Brain Research, Leipzig University, Leipzig, Germany, ⁵Department of Anatomy and Embryology, Maastricht University, Maastricht, Netherlands, ⁶Felix Bloch Institute for Solid State Physics, Leipzig University, Leipzig, Germany

Synopsis

Keywords: Parkinson's Disease, Multimodal, Atlas, Subcortex

MRI holds great promise to unravel the selective vulnerability and functional differentiation of the nigrosomes in the human substantia nigra pars compacta. Based on block-face imaging and calbindin-D28K immunohistochemistry, we constructed a 3D nigrosome atlas. Using this atlas, we demonstrate several nigrosomes to show increased R2* values in post mortem tissue. Our results further challenge the common identification of the nigrosomes with hyperintense structures in in vivo MRI, particularly nigrosome 1 and the swallow tail sign.

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