Keywords: Parkinson's Disease, Normal developmentAn optimized clinically feasible neuromelanin MRI imaging protocol for visualising the SN and LC simultaneously using deep learning reconstruction is presented. For a 2D sequence we set out to optimize the flip-angle for optimal combined SN and LC depiction. We also experimented with combinations of anisotropic and isotropic in-plane resolution, partial vs full echoes and the number of averages. Phantom and in-vivo experiments on three healthy volunteers illustrate that high-resolution imaging combined with deep-learning denoising shows good depiction of the SN and LC with a clinically feasible sequence of 7 minutes.
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