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Abstract #1394

Visualizing Neuromelanin in Parkinson’s disease in the presence of motion

Mikael Skorpil1, Henric Rydén2, Per Svenningsson2, and Adam van Niekerk2
1Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, 2Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden

Synopsis

Keywords: Parkinson's Disease, Motion CorrectionNeuromelanin-MRI can detect reductions in volume and intensity of the substantia nigra in Parkinson’s disease (PD). High-resolution magnetization transfer (MT) contrast T1-weighted sequences are used, and the MT pulse is time-consuming. We evaluated the degree of motion during a long (~ 12 min) scan in a PD patient and a healthy volunteer, and the effect of motion correction using a wireless RF-triggered acquisition device (WRAD) developed in our group. Despite only minor motion, for both participants, motion correction improved image quality.

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